Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance

The nonopioid actions of spinal dynorphin may promote aspects of abnormal pain after nerve injury. Mechanistic similarities have been suggested between opioid tolerance and neuropathic pain. Here, the hypothesis that spinal dynorphin might mediate effects of sustained spinal opioids was explored. Po...

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Pubblicato in:J Neurosci
Autori principali: Vanderah, Todd W., Gardell, Luis R., Burgess, Shannon E., Ibrahim, Mohab, Dogrul, Ahmet, Zhong, Cheng-Min, Zhang, En-Tan, Malan, T. Philip, Ossipov, Michael H., Lai, Josephine, Porreca, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772839/
https://ncbi.nlm.nih.gov/pubmed/10995854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-18-07074.2000
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