Pretargeted radioimmunotherapy and SPECT imaging of peritoneal carcinomatosis using bioorthogonal click chemistry: probe selection and first proof-of-concept

Rationale: Pretargeted radioimmunotherapy (PRIT) based upon bioorthogonal click chemistry has been investigated for the first time in the context of peritoneal carcinomatosis using a CEA-targeting 35A7 mAb bearing trans-cyclooctene (TCO) moieties and several (177)Lu-labeled tetrazine (Tz) radioligan...

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Dades bibliogràfiques
Publicat a:Theranostics
Autors principals: Rondon, Aurélie, Schmitt, Sébastien, Briat, Arnaud, Ty, Nancy, Maigne, Lydia, Quintana, Mercedes, Membreno, Rosemery, Zeglis, Brian M., Navarro-Teulon, Isabelle, Pouget, Jean-Pierre, Chezal, Jean-Michel, Miot-Noirault, Elisabeth, Moreau, Emmanuel, Degoul, Françoise
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771248/
https://ncbi.nlm.nih.gov/pubmed/31588245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35461
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