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Towards the Optimization of Click-Mediated Pretargeted Radioimmunotherapy

Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder reaction has shown promise in murine models of disease, yet the radiation dosimetry of this approach must be optimized to make it a viable clinical option. To this end, we have leveraged two recent developments in...

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Publicado en:Mol Pharm
Autores principales: Membreno, Rosemery, Keinänen, Outi M., Cook, Brendon E., Tully, Kathryn M., Fung, Kimberly C., Lewis, Jason S., Zeglis, Brian M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047588/
https://ncbi.nlm.nih.gov/pubmed/30912951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00062
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