Click-Mediated Pretargeted Radioimmunotherapy of Colorectal Carcinoma

Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) represents a promising strategy for leveraging the affinity and specificity of antibodies without their pharmacokinetic drawbacks. Herein, we pre...

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Bibliografiske detaljer
Udgivet i:Mol Pharm
Main Authors: Membreno, Rosemery, Cook, Brendon E., Fung, Kimberly, Lewis, Jason S., Zeglis, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467224/
https://ncbi.nlm.nih.gov/pubmed/29502416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00093
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