Establishment of the in vivo efficacy of pretargeted radioimmunotherapy utilizing inverse electron demand Diels-Alder click chemistry

The pretargeting system based on the inverse electron demand Diels-Alder reaction (IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable pharmacokinetic properties of radiolabeled small molecules with the affinity and specificity of antibodies. This strategy has proven to...

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Publicat a:Mol Cancer Ther
Autors principals: Houghton, Jacob L., Membreno, Rosemery, Abdel-Atti, Dalya, Cunanan, Kristen M., Carlin, Sean, Scholz, Wolfgang W., Zanzonico, Pat B., Lewis, Jason S., Zeglis, Brian M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221649/
https://ncbi.nlm.nih.gov/pubmed/28062708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0503
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