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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

While radioimmunotherapy (RIT) is a promising approach for the treatment of cancer, the long pharmacokinetic half-life of radiolabeled antibodies can result in high radiation doses to healthy tissues. Perhaps not surprisingly, several different strategies have been developed to circumvent this troub...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Membreno, Rosemery, Cook, Brendon E., Zeglis, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7169957/
https://ncbi.nlm.nih.gov/pubmed/30774125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59041
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