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Leveraging bioorthogonal click chemistry to improve (225)Ac-radioimmunotherapy of pancreatic ductal adenocarcinoma

PURPOSE: Interest in targeted alpha-therapy has surged due to α-particles’ high cytotoxicity. However, the widespread clinical use of this approach could be limited by on-/off-target toxicities. Here, we investigated the inverse electron-demand Diels-Alder ligation between an (225)Ac-labeled tetrazi...

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Publicado en:Clin Cancer Res
Main Authors: Poty, Sophie, Carter, Lukas M., Mandleywala, Komal, Membreno, Rosemery, Abdel-Atti, Dalya, Ragupathi, Ashwin, Scholz, Wolfgang W., Zeglis, Brian M., Lewis, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343144/
https://ncbi.nlm.nih.gov/pubmed/30352909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1650
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