Loss of MCU prevents mitochondrial fusion in G1/S phase and blocks cell cycle progression and proliferation

The role of the mitochondrial Ca(2+) uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during cell cycling. During the G1/S transition (the cycle phase with the highest mitocho...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Koval, Olha M., Nguyen, Emily K., Santhana, Velarchana, Fidler, Trevor P., Sebag, Sara C., Rasmussen, Tyler P., Mittauer, Dylan J., Strack, Stefan, Goswami, Prabhat C., Abel, E. Dale, Grumbach, Isabella M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768401/
https://ncbi.nlm.nih.gov/pubmed/31040260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav1439
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