Loss of MCU prevents mitochondrial fusion in G1/S phase and blocks cell cycle progression and proliferation

The role of the mitochondrial Ca(2+) uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during cell cycling. During the G1/S transition (the cycle phase with the highest mitocho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Signal
Prif Awduron: Koval, Olha M., Nguyen, Emily K., Santhana, Velarchana, Fidler, Trevor P., Sebag, Sara C., Rasmussen, Tyler P., Mittauer, Dylan J., Strack, Stefan, Goswami, Prabhat C., Abel, E. Dale, Grumbach, Isabella M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768401/
https://ncbi.nlm.nih.gov/pubmed/31040260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav1439
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