Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Myocardial mitochondrial Ca(2+) entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca(2+) are lacking. We developed a mouse model with myocardial delimited transgenic expression of a dom...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Rasmussen, Tyler P., Wu, Yuejin, Joiner, Mei-ling A., Koval, Olha M., Wilson, Nicholas R., Luczak, Elizabeth D., Wang, Qinchuan, Chen, Biyi, Gao, Zhan, Zhu, Zhiyong, Wagner, Brett A., Soto, Jamie, McCormick, Michael L., Kutschke, William, Weiss, Robert M., Yu, Liping, Boudreau, Ryan L., Abel, E. Dale, Zhan, Fenghuang, Spitz, Douglas R., Buettner, Garry R., Song, Long-Sheng, Zingman, Leonid V., Anderson, Mark E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517214/
https://ncbi.nlm.nih.gov/pubmed/26153425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504705112
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