Ca(V)1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations

Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and vo...

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Hlavní autoři: Koval, Olha M., Guan, Xiaoquan, Wu, Yuejin, Joiner, Mei-ling, Gao, Zhan, Chen, Biyi, Grumbach, Isabella M., Luczak, Elizabeth D., Colbran, Roger J., Song, Long-Sheng, Hund, Thomas J., Mohler, Peter J., Anderson, Mark E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841943/
https://ncbi.nlm.nih.gov/pubmed/20194790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913760107
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