Catecholamine-Independent Heart Rate Increases Require CaMKII

BACKGROUND: Catecholamines increase heart rate by augmenting the cAMP responsive HCN4 ‘pacemaker current’ (I(f)) and/or by promoting inward Na(+)/Ca(2+) exchanger current (I(NCX)), by a ‘Ca(2+) clock’ mechanism in sinoatrial nodal cells (SANCs). The importance, identity and function of signals that...

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Bibliographic Details
Main Authors: Gao, Zhan, Singh, Madhu V, Hall, Duane D, Koval, Olha M., Luczak, Elizabeth D., Joiner, Mei-ling A., Chen, Biyi, Wu, Yuejin, Chaudhary, Ashok K, Martins, James B, Hund, Thomas J, Mohler, Peter J, Song, Long-Sheng, Anderson, Mark E.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116039/
https://ncbi.nlm.nih.gov/pubmed/21406683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.110.961771
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