Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Myocardial mitochondrial Ca(2+) entry enables physiological stress responses but in excess promotes injury and death. However, tissue-specific in vivo systems for testing the role of mitochondrial Ca(2+) are lacking. We developed a mouse model with myocardial delimited transgenic expression of a dom...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Rasmussen, Tyler P., Wu, Yuejin, Joiner, Mei-ling A., Koval, Olha M., Wilson, Nicholas R., Luczak, Elizabeth D., Wang, Qinchuan, Chen, Biyi, Gao, Zhan, Zhu, Zhiyong, Wagner, Brett A., Soto, Jamie, McCormick, Michael L., Kutschke, William, Weiss, Robert M., Yu, Liping, Boudreau, Ryan L., Abel, E. Dale, Zhan, Fenghuang, Spitz, Douglas R., Buettner, Garry R., Song, Long-Sheng, Zingman, Leonid V., Anderson, Mark E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517214/
https://ncbi.nlm.nih.gov/pubmed/26153425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504705112
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