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Loss of MCU prevents mitochondrial fusion in G1/S phase and blocks cell cycle progression and proliferation
The role of the mitochondrial Ca(2+) uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during cell cycling. During the G1/S transition (the cycle phase with the highest mitocho...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6768401/ https://ncbi.nlm.nih.gov/pubmed/31040260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav1439 |
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