Loss of MCU prevents mitochondrial fusion in G1/S phase and blocks cell cycle progression and proliferation

The role of the mitochondrial Ca(2+) uniporter (MCU) in physiologic cell proliferation remains to be defined. Here, we demonstrated that the MCU was required to match mitochondrial function to metabolic demands during cell cycling. During the G1/S transition (the cycle phase with the highest mitocho...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Signal
Hlavní autoři: Koval, Olha M., Nguyen, Emily K., Santhana, Velarchana, Fidler, Trevor P., Sebag, Sara C., Rasmussen, Tyler P., Mittauer, Dylan J., Strack, Stefan, Goswami, Prabhat C., Abel, E. Dale, Grumbach, Isabella M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768401/
https://ncbi.nlm.nih.gov/pubmed/31040260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav1439
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky