Mitochondrial Calcium Uniporter Regulates Metabolic Remodeling and Smooth Muscle Cell Proliferation in Type 2 Diabetes

Background Excessive proliferation of vascular smooth muscle cells (VSMCs) is a consequence of type 2 diabetes (T2D) that increases the risk for atherosclerosis and restenosis after angioplasty. Here, we sought to determine whether and how mitochondrial dysfunction in T2D drives VSMC proliferation w...

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Autori principali: Olha M. Koval, Emily K. Nguyen, Dylan J. Mittauer, Jane L. Buchanan, Kyle Westhoff, Dao‐Fu Dai, Eric B. Taylor, Isabella M. Grumbach
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2025-08-01
Serie:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Soggetti:
diabetes
metabolism
mitochondria
neointima
vascular smooth muscle cells
Accesso online:https://www.ahajournals.org/doi/10.1161/JAHA.124.039220
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