Inhibition of CaMKII in Mitochondria Preserves Endothelial Barrier Function After Irradiation

Damage to the microvascular endothelium is an important part of normal tissue injury after radiation exposure and driven by the production of pro-oxidants. The Ca(2+)/calmodulin-dependent protein kinase II is present in the mitochondrial matrix (mitoCaMKII) where it regulates Ca(2+) uptake via the m...

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Udgivet i:Free Radic Biol Med
Main Authors: Roy, Stephen J., Koval, Olha M., Sebag, Sara C., Ait-Aissa, Karima, Allen, Bryan G., Spitz, Douglas R., Grumbach, Isabella M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274136/
https://ncbi.nlm.nih.gov/pubmed/31711984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.11.012
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