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CaMKII (Ca(2+)/calmodulin-dependent kinase II) in mitochondria of smooth muscle cells controls mitochondrial mobility, migration and neointima formation

OBJECTIVE: To define the mechanisms by which mitochondria control VSMC migration and impact neointimal hyperplasia. APPROACH AND RESULTS: The multifunctional Ca(2+)/calmodulin-dependent kinase II (CaMKII) in the mitochondrial matrix of VSMC drove a feed-forward circuit with the mitochondrial Ca(2+)...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Nguyen, Emily K., Koval, Olha M., Noble, Paige, Broadhurst, Kim, Allamargot, Chantal, Wu, Meng, Strack, Stefan, Thiel, William H., Grumbach, Isabella M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970052/
https://ncbi.nlm.nih.gov/pubmed/29599132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.310951
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