SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage

Eukaryotic cells have developed sophisticated mechanisms to ensure the integrity of the genome and prevent the transmission of altered genetic information to daughter cells. If this control system fails, accumulation of mutations would increase risk of diseases such as cancer. Ubiquitylation, an ess...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Galindo-Moreno, María, Giráldez, Servando, Limón-Mortés, M. Cristina, Belmonte-Fernández, Alejandro, Reed, Steven I., Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766643/
https://ncbi.nlm.nih.gov/pubmed/31337255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900885R
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