Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer

Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition downregulates survival and induces apoptosis. Due to its essential role, CDK1 expression and activity are strictly controlled at va...

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Foilsithe in:Sci Rep
Main Authors: Galindo-Moreno, María, Giráldez, Servando, Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577189/
https://ncbi.nlm.nih.gov/pubmed/28855742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10506-8
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