SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage

Eukaryotic cells have developed sophisticated mechanisms to ensure the integrity of the genome and prevent the transmission of altered genetic information to daughter cells. If this control system fails, accumulation of mutations would increase risk of diseases such as cancer. Ubiquitylation, an ess...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Galindo-Moreno, María, Giráldez, Servando, Limón-Mortés, M. Cristina, Belmonte-Fernández, Alejandro, Reed, Steven I., Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766643/
https://ncbi.nlm.nih.gov/pubmed/31337255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900885R
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