SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability

The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response to replication stress. When DNA lesions are detected, replication fork progression is blocked allowing time for repair to avoid genomic instability and the risk of cancer. DNA repl...

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Detalhes bibliográficos
Main Authors: Giráldez, Servando, Herrero-Ruiz, Joaquín, Mora-Santos, Mar, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147330/
https://ncbi.nlm.nih.gov/pubmed/24970797
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