SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability

The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response to replication stress. When DNA lesions are detected, replication fork progression is blocked allowing time for repair to avoid genomic instability and the risk of cancer. DNA repl...

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Bibliographische Detailangaben
Hauptverfasser: Giráldez, Servando, Herrero-Ruiz, Joaquín, Mora-Santos, Mar, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147330/
https://ncbi.nlm.nih.gov/pubmed/24970797
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