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Polymerase synthesis of four-base DNA from two stable dimeric nucleotides

We document the preparation and properties of dimerized pentaphosphate-bridged deoxynucleotides (dicaptides) that contain reactive components of two different nucleotides simultaneously. Importantly, dicaptides are found to be considerably more stable to hydrolysis than standard dNTPs. Steady-state...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Mohsen, Michael G, Ji, Debin, Kool, Eric T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765132/
https://ncbi.nlm.nih.gov/pubmed/31504784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz741
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