Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

DNA methylation regulates gene expression in a variety of processes, including mouse embryonic development. Four catalytically active enzymes function in mice as DNA methyltransferases (Dnmts) and as transcriptional regulators. Inactivation of Dnmt3b results in mouse embryonic lethality, but which a...

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Udgivet i:Nat Commun
Main Authors: Nowialis, Pawel, Lopusna, Katarina, Opavska, Jana, Haney, Staci L., Abraham, Ajay, Sheng, Peike, Riva, Alberto, Natarajan, Amarnath, Guryanova, Olga, Simpson, Melanie, Hlady, Ryan, Xie, Mingyi, Opavsky, Rene
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763448/
https://ncbi.nlm.nih.gov/pubmed/31558711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12355-7
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