Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

DNA methyltransferase 3A (DNMT3A) is an enzyme involved in DNA methylation that is frequently mutated in human hematologic malignancies. We have previously shown that inactivation of Dnmt3a in hematopoietic cells results in chronic lymphocytic leukemia in mice. Here we show that 12% of Dnmt3a-defici...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Principais autores: Haney, Staci L., Upchurch, G. Michael, Opavska, Jana, Klinkebiel, David, Hlady, Ryan A., Roy, Sohini, Dutta, Samikshan, Datta, Kaustubh, Opavsky, Rene
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045215/
https://ncbi.nlm.nih.gov/pubmed/27690235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006334
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