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Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice
Cytosine methylation of DNA is an epigenetic modification involved in the repression of genes that affect biological processes including hematopoiesis. It is catalyzed by DNA methyltransferases, one of which -DNMT3A- is frequently mutated in human hematologic malignancies. We have previously reporte...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5039761/ https://ncbi.nlm.nih.gov/pubmed/27677595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34222 |
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