Promoter hypomethylation and expression is conserved in mouse chronic lymphocytic leukemia induced by decreased or inactivated Dnmt3a

DNA methyltransferase 3a (DNMT3A) catalyzes the formation of 5-methyl-cytosine in mammalian genomic DNA and it is frequently mutated in human hematologic malignancies. Bi-allelic loss of Dnmt3a in mice results in leukemia and lymphoma, including chronic lymphocytic leukemia (CLL). Here we investigat...

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Publicado no:Cell Rep
Main Authors: Haney, Staci L., Upchurch, G. Michael, Opavska, Jana, Klinkebiel, David, Hlady, Ryan A., Suresh, Abhinav, Pirruccello, Samuel J., Shukla, Vipul, Lu, Runqing, Costinean, Stefan, Rizzino, Angie, Karpf, Adam R., Joshi, Shantaram, Swanson, Patrick, Opavsky, Rene
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864108/
https://ncbi.nlm.nih.gov/pubmed/27134162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.004
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