Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

DNA methyltransferase 3A (DNMT3A) is an enzyme involved in DNA methylation that is frequently mutated in human hematologic malignancies. We have previously shown that inactivation of Dnmt3a in hematopoietic cells results in chronic lymphocytic leukemia in mice. Here we show that 12% of Dnmt3a-defici...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Haney, Staci L., Upchurch, G. Michael, Opavska, Jana, Klinkebiel, David, Hlady, Ryan A., Roy, Sohini, Dutta, Samikshan, Datta, Kaustubh, Opavsky, Rene
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045215/
https://ncbi.nlm.nih.gov/pubmed/27690235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006334
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