Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

Dose is an important parameter in terms of both efficacy and adverse effects in pharmacological treatment of atrial fibrillation (AF). Both of the class III antiarrhythmics dofetilide and amiodarone have documented anti-AF effects. While dofetilide has dose-related ventricular side effects, amiodaro...

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Vydáno v:Pflugers Arch
Hlavní autoři: Kirchhoff, Jeppe Egedal, Diness, Jonas Goldin, Abildgaard, Lea, Sheykhzade, Majid, Grunnet, Morten, Jespersen, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2016
Témata:
Ion Channels, Receptors and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763419/
https://ncbi.nlm.nih.gov/pubmed/27722784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-016-1883-9
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