Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

Dose is an important parameter in terms of both efficacy and adverse effects in pharmacological treatment of atrial fibrillation (AF). Both of the class III antiarrhythmics dofetilide and amiodarone have documented anti-AF effects. While dofetilide has dose-related ventricular side effects, amiodaro...

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Detalles Bibliográficos
Publicado en:Pflugers Arch
Main Authors: Kirchhoff, Jeppe Egedal, Diness, Jonas Goldin, Abildgaard, Lea, Sheykhzade, Majid, Grunnet, Morten, Jespersen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2016
Assuntos:
Ion Channels, Receptors and Transporters
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763419/
https://ncbi.nlm.nih.gov/pubmed/27722784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-016-1883-9
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