A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (K(Ca)2) channels

BACKGROUND AND PURPOSE: Small conductance calcium‐activated potassium (K(Ca)2) channels represent a promising atrial‐selective target for treatment of atrial fibrillation. Here, we establish the mechanism of K(Ca)2 channel inhibition by the new compound AP14145. EXPERIMENTAL APPROACH: Using site‐dir...

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Publicat a:Br J Pharmacol
Autors principals: Simó‐Vicens, Rafel, Kirchhoff, Jeppe E, Dolce, Bernardo, Abildgaard, Lea, Speerschneider, Tobias, Sørensen, Ulrik S, Grunnet, Morten, Diness, Jonas G, Bentzen, Bo H
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715977/
https://ncbi.nlm.nih.gov/pubmed/28925012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14043
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