The K(Ca)2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (I(Kr)) is inhibited. The current mediated by K(Ca)2-channels, I(KCa), is considered a promising new target for...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Kirchhoff, Jeppe Egedal, Skarsfeldt, Mark Alexander, Muthukumarasamy, Kalai Mangai, Simó-Vicens, Rafel, Bomholtz, Sofia Hammami, Abildgaard, Lea, Jespersen, Thomas, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth, Diness, Jonas Goldin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593233/
https://ncbi.nlm.nih.gov/pubmed/31275147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00668
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