NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide

Aims: The small conductance calcium activated potassium channel (KCNN1-3; KCa2.1–3) is recognized as a possible new anti-arrhythmic drug target for treatment of atrial fibrillation (AF). The aim of this study is to investigate potential ventricular effects of KCa2 channel inhibition under normal, br...

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ग्रंथसूची विवरण

मुख्य लेखकों:	Yannan Yan, Lea Abildgaard, Mark Alexander Skarsfeldt, Sofia Hammami Bomholtz, Ulrik Sørensen, Anders Gaarsdal Holst, Morten Grunnet, Jonas Goldin Diness, Bo Hjorth Bentzen
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2025-08-01
श्रृंखला:	International Journal of Cardiology: Heart & Vasculature
विषय:	KCa2 channels SK channels Hypokalemia QT-interval Pharmacology Arrhythmia
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2352906725001022
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