Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

AimsSmall conductance Ca2+-activated K+ channels (SK channels, KCa2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of KCa2 channels that is currently in clinical development for treatment of AF. The aim of this study is to present the electrophysio...

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Hlavní autoři:	Bo Hjorth Bentzen, Sofia Hammami Bomholtz, Rafel Simó-Vicens, Lasse Folkersen, Lea Abildgaard, Tobias Speerschneider, Kalai Mangai Muthukumarasamy, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Jonas Goldin Diness
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-05-01
Edice:	Frontiers in Pharmacology
Témata:	atrial fibrillation ion channels anti-arrhythmic drugs SK channels KCa2
On-line přístup:	https://www.frontiersin.org/article/10.3389/fphar.2020.00610/full
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