Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage

Prostate cancer (PC) initially depends on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leadin...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Chatterjee, Payel, Schweizer, Michael T., Lucas, Jared M., Coleman, Ilsa, Nyquist, Michael D., Frank, Sander B., Tharakan, Robin, Mostaghel, Elahe, Luo, Jun, Pritchard, Colin C., Lam, Hung-Ming, Corey, Eva, Antonarakis, Emmanuel S., Denmeade, Samuel R., Nelson, Peter S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763228/
https://ncbi.nlm.nih.gov/pubmed/31310591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127613
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