Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage

Prostate cancer (PC) initially depends on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leadin...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Chatterjee, Payel, Schweizer, Michael T., Lucas, Jared M., Coleman, Ilsa, Nyquist, Michael D., Frank, Sander B., Tharakan, Robin, Mostaghel, Elahe, Luo, Jun, Pritchard, Colin C., Lam, Hung-Ming, Corey, Eva, Antonarakis, Emmanuel S., Denmeade, Samuel R., Nelson, Peter S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763228/
https://ncbi.nlm.nih.gov/pubmed/31310591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127613
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