Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage

Prostate cancer (PC) initially depends on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leadin...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Chatterjee, Payel, Schweizer, Michael T., Lucas, Jared M., Coleman, Ilsa, Nyquist, Michael D., Frank, Sander B., Tharakan, Robin, Mostaghel, Elahe, Luo, Jun, Pritchard, Colin C., Lam, Hung-Ming, Corey, Eva, Antonarakis, Emmanuel S., Denmeade, Samuel R., Nelson, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763228/
https://ncbi.nlm.nih.gov/pubmed/31310591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127613
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