Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage

Prostate cancer (PC) initially depends on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leadin...

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Vydáno v:J Clin Invest
Hlavní autoři: Chatterjee, Payel, Schweizer, Michael T., Lucas, Jared M., Coleman, Ilsa, Nyquist, Michael D., Frank, Sander B., Tharakan, Robin, Mostaghel, Elahe, Luo, Jun, Pritchard, Colin C., Lam, Hung-Ming, Corey, Eva, Antonarakis, Emmanuel S., Denmeade, Samuel R., Nelson, Peter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763228/
https://ncbi.nlm.nih.gov/pubmed/31310591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127613
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