Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage

Prostate cancer (PC) initially depends on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leadin...

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發表在:J Clin Invest
Main Authors: Chatterjee, Payel, Schweizer, Michael T., Lucas, Jared M., Coleman, Ilsa, Nyquist, Michael D., Frank, Sander B., Tharakan, Robin, Mostaghel, Elahe, Luo, Jun, Pritchard, Colin C., Lam, Hung-Ming, Corey, Eva, Antonarakis, Emmanuel S., Denmeade, Samuel R., Nelson, Peter S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763228/
https://ncbi.nlm.nih.gov/pubmed/31310591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127613
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