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Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage
Prostate cancer (PC) initially depends on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leadin...
Zapisane w:
| Wydane w: | J Clin Invest |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6763228/ https://ncbi.nlm.nih.gov/pubmed/31310591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127613 |
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