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Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Since Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Mohammad, Osama S., Nyquist, Michael D., Schweizer, Michael T., Balk, Stephen P., Corey, Eva, Plymate, Stephen, Nelson, Peter S., Mostaghel, Elahe A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742814/
https://ncbi.nlm.nih.gov/pubmed/29210989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9120166
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