Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts

BACKGROUND: Androgen deprivation therapy improves the survival of castration-resistant prostate cancer (CRPC) patients, yet ultimately fails with debilitating side effects. Supraphysiological testosterone (SPT)-based therapy produces clinical responses with improved quality of life in a subset of pa...

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Detalhes bibliográficos
Publicado no:Eur Urol
Main Authors: Lam, Hung-Ming, Nguyen, Holly M., Labrecque, Mark P., Brown, Lisha G., Coleman, Ilsa M., Gulati, Roman, Lakely, Bryce, Sondheim, Daniel, Chatterjee, Payel, Marck, Brett T., Matsumoto, Alvin M., Mostaghel, Elahe A., Schweizer, Michael T., Nelson, Peter S., Corey, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920609/
https://ncbi.nlm.nih.gov/pubmed/31227306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2019.05.042
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