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Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity

Polychlorinated biphenyls (PCBs) have been associated with neurodevelopmental disorders. Several neurotoxic congeners display axial chirality and atropselectively affect cellular targets implicated in PCB neurotoxicity. Only limited information is available regarding the atropselective metabolism of...

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書目詳細資料
發表在:Toxicol Sci
Main Authors: Uwimana, Eric, Cagle, Brianna, Yeung, Coby, Li, Xueshu, Patterson, Eric V, Doorn, Jonathan A, Lehmler, Hans-Joachim
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760323/
https://ncbi.nlm.nih.gov/pubmed/31268529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz150
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