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Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity

Polychlorinated biphenyls (PCBs) have been associated with neurodevelopmental disorders. Several neurotoxic congeners display axial chirality and atropselectively affect cellular targets implicated in PCB neurotoxicity. Only limited information is available regarding the atropselective metabolism of...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Uwimana, Eric, Cagle, Brianna, Yeung, Coby, Li, Xueshu, Patterson, Eric V, Doorn, Jonathan A, Lehmler, Hans-Joachim
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760323/
https://ncbi.nlm.nih.gov/pubmed/31268529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz150
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