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2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes

[Image: see text] Exposure to neurotoxic, chiral PCBs has been associated with neurodevelopmental disorders, but their metabolism in humans remains unexplored. We investigated the enantioselective metabolism of PCB 95 by human liver microsomes (HLMs) to potentially neurotoxic, hydroxylated metabolit...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Uwimana, Eric, Li, Xueshu, Lehmler, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175585/
https://ncbi.nlm.nih.gov/pubmed/27989147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00371
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