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HUMAN CYP2A6, CYP2B6 AND CYP2E1 ATROPSELECTIVELY METABOLIZE POLYCHLORINATED BIPHENYLS TO HYDROXYLATED METABOLITES

Exposure to chiral polychlorinated biphenyls (PCBs) has been associated with neurodevelopmental disorders. Their hydroxylated metabolites (OH-PCBs) are also potentially toxic to the developing human brain; however, the formation of OH-PCBs by human cytochrome P450 (P450) isoforms is poorly investiga...

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Détails bibliographiques
Publié dans:Environ Sci Technol
Auteurs principaux: Uwimana, Eric, Ruiz, Patricia, Li, Xueshu, Lehmler, Hans-Joachim
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380921/
https://ncbi.nlm.nih.gov/pubmed/30576102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.est.8b05250
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