2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is Enantioselectively Oxidized to Hydroxylated Metabolites by Rat Liver Microsomes

Developmental exposure to multiple-ortho substituted polychlorinated biphenyls (PCBs) causes adverse neurodevelopmental outcomes in laboratory animals and humans by mechanisms involving the sensitization of Ryanodine receptors (RyRs). In the case of PCB 136, the sensitization of RyR is enantiospecif...

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Detalhes bibliográficos
Main Authors: Wu, Xianai, Pramanik, Ananya, Duffel, Michael W., Hrycay, Eugene G., Bandiera, Stelvio M., Lehmler, Hans-Joachim, Kania-Korwel, Izabela
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243785/
https://ncbi.nlm.nih.gov/pubmed/22026639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200360m
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