2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is Enantioselectively Oxidized to Hydroxylated Metabolites by Rat Liver Microsomes

Developmental exposure to multiple-ortho substituted polychlorinated biphenyls (PCBs) causes adverse neurodevelopmental outcomes in laboratory animals and humans by mechanisms involving the sensitization of Ryanodine receptors (RyRs). In the case of PCB 136, the sensitization of RyR is enantiospecif...

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Bibliografiske detaljer
Main Authors: Wu, Xianai, Pramanik, Ananya, Duffel, Michael W., Hrycay, Eugene G., Bandiera, Stelvio M., Lehmler, Hans-Joachim, Kania-Korwel, Izabela
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243785/
https://ncbi.nlm.nih.gov/pubmed/22026639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200360m
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