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2,2′,3,3′,6,6′-Hexachlorobiphenyl (PCB 136) Atropisomers Interact Enantioselectively with Hepatic Microsomal Cytochrome P450 Enzymes

2,2′,3,3′,6,6′-Hexachlorobiphenyl (PCB 136) is a chiral and highly neurotoxic PCB congener of environmental relevance. (+)-PCB 136 was previously shown to be enriched in tissues from mice treated with racemic PCB 136. We investigated the spectral interactions of (+)-, (-)- and (±)-PCB 136 with mouse...

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Detalhes bibliográficos
Main Authors: Kania-Korwel, Izabela, Hrycay, Eugene G., Bandiera, Stelvio M., Lehmler, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574739/
https://ncbi.nlm.nih.gov/pubmed/18494506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800059j
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