Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Causes Neurotoxicity by Clathrin-Dependent Endocytosis

GGGGCC repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). It has been reported that hexanucleotide repeat expansions in C9ORF72 produce five dipeptide repeat (DPR) proteins by an unconventional repeat-associated n...

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Detalles Bibliográficos
Publicado en:Neurosci Bull
Main Authors: Wang, Rui, Xu, Xingyun, Hao, Zongbing, Zhang, Shun, Wu, Dan, Sun, Hongyang, Mu, Chenchen, Ren, Haigang, Wang, Guanghui
Formato: Artigo
Idioma:Inglês
Publicado: Springer Singapore 2019
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754483/
https://ncbi.nlm.nih.gov/pubmed/31148094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-019-00395-4
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