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Tyrosine hydroxylase down-regulation after loss of Abelson helper integration site 1 (AHI1) promotes depression via the circadian clock pathway in mice

Abelson helper integration site 1 (AHI1) is associated with several neuropsychiatric and brain developmental disorders, such as schizophrenia, depression, autism, and Joubert syndrome. Ahi1 deficiency in mice leads to behaviors typical of depression. However, the mechanisms by which AHI1 regulates b...

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Publicado en:J Biol Chem
Autores principales: Guo, Dongkai, Zhang, Shun, Sun, Hongyang, Xu, Xingyun, Hao, Zongbing, Mu, Chenchen, Xu, Xingshun, Wang, Guanghui, Ren, Haigang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892572/
https://ncbi.nlm.nih.gov/pubmed/29449373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000618
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