Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR

A GGGGCC hexanucleotide repeat expansion in intron 1 of chromosome 9 open reading frame 72 (C9ORF72) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Repeat-associated non-ATG translation of dipeptide repeat proteins (DPRs) contributes to the...

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Publicat a:Nat Commun
Autors principals: Hao, Zongbing, Liu, Liu, Tao, Zhouteng, Wang, Rui, Ren, Haigang, Sun, Hongyang, Lin, Zixuan, Zhang, Zhixiong, Mu, Chenchen, Zhou, Jiawei, Wang, Guanghui
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606620/
https://ncbi.nlm.nih.gov/pubmed/31266945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10956-w
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