Impact of linker-drug on ion exchange chromatography separation of antibody-drug conjugates

Charge variants are important attributes of monoclonal antibodies, including antibody-drug conjugates (ADCs), because charge variants can potentially influence the stability and biological activity of these molecules. Ion exchange chromatography (IEX) is widely used for charge variants analysis of m...

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Publicado en:MAbs
Autores principales: Zhang, Zhaorui, Zhou, Shiyue, Han, Linjie, Zhang, Qunying, Pritts, Wayne A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748606/
https://ncbi.nlm.nih.gov/pubmed/31238787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1628589
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