High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry

Antibody-drug conjugates (ADCs) are one of the fastest growing classes of anticancer therapies. Combining the high targeting specificity of monoclonal antibodies (mAbs) with cytotoxic small molecule drugs, ADCs are complex molecular entities that are intrinsically heterogeneous. Primary sequence var...

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Udgivet i:Anal Chem
Main Authors: Larson, Eli J., Roberts, David S., Melby, Jake A., Buck, Kevin M., Zhu, Yanlong, Zhou, Shiyue, Han, Linjie, Zhang, Qunying, Ge, Ying
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319120/
https://ncbi.nlm.nih.gov/pubmed/34258999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.1c00150
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