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Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation

Antibody-drug conjugates (ADCs) are designed to combine the target specificity of monoclonal antibodies and potent cytotoxin drugs to achieve better therapeutic outcome. Comprehensive evaluation of the quality attributes of ADCs is critical for drug development but remains challenging due to heterog...

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Bibliografiske detaljer
Udgivet i:Anal Chem
Main Authors: Chen, Bifan, Lin, Ziqing, Zhu, Yanlong, Jin, Yutong, Larson, Eli, Xu, Qingge, Fu, Cexiong, Zhang, Zhaorui, Zhang, Qunying, Pritts, Wayne A., Ge, Ying
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493829/
https://ncbi.nlm.nih.gov/pubmed/31442030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b02194
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