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Single-molecule correlated chemical probing reveals large-scale structural communication in the ribosome and the mechanism of the antibiotic spectinomycin in living cells

The ribosome moves between distinct structural states and is organized into multiple functional domains. Here, we examined hundreds of occurrences of pairwise through-space communication between nucleotides in the ribosome small subunit RNA using RNA interaction groups analyzed by mutational profili...

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Foilsithe in:PLoS Biol
Main Authors: Sengupta, Arnab, Rice, Greggory M., Weeks, Kevin M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748448/
https://ncbi.nlm.nih.gov/pubmed/31487286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000393
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